Santi Cazorla made no mistake from the spot as he sealed the 2-1 victory, ensuring Arsenal walk away with maximum points from the encounter.
FC's Craig Burley explains how new signings Shkodran Mustafi and Lucas Perez will influence Arsenal.
The Premier League, however, is not a competition in which big clubs can take liberties with team selection and Southampton started the sharper and took a deserved lead.
Arsene Wenger breathed a sigh of relief after Arsenal won a stoppage-time penalty against Southampton and Santi Cazorla struck a 94th-minute victor to secure a 2-1 win on Saturday (Sept 10).
Speaking after the game, the Arsenal boss said, "It's a relief".
The only positive I can find is that we finally beat Southampton after not scoring against them for the last three meetings, but if we are totally honest, it was not impressive and we don't look like title challengers, despite Wenger thinking we now have a "complete squad".
"They were a bit on their nerves in the first half, but in the second half they were much better". We played the first 30 minutes fantastic.
Heung-Min Son, brought in for Erik Lamela after he played for Argentina in midweek, scored with two first-time finishes either side of the interval and England internationals Dele Alli and Harry Kane, both of whom scored doubles back in April, then found the net for the first time this season.
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"Because we threw everything forward we were always a little bit under threat on the counter-attack of Southampton and in the end we got the penalty, so it's a relief".
Wilfried Zaha's opportunist strike handed Crystal Palace a 2-1 win, their first of the Premier League season as Middlesbrough's unbeaten start came to a disappointing end.
"When you lose the first home game you can not afford to drop points in the second".
Mesut Ozil went looking for Perez after a bright spell from the hosts, with Jose Fonte cutting out the pass. Alex Oxlade-Chamberlain didn't fare much better.
Arsenal have won their last two league fixtures, while Southampton are still searching for their first win of the campaign.
Arsenal's match-winner Cazorla, meanwhile, added: "I had a lot of time to think about where to shoot my penalty, but I kept calm".
The Spaniard excelled alongside Granit Xhaka against the Hornets, but the German was rested ahead of Tuesday's crucial Champions League tie against Paris Saint-Germain, as Francis Coquelin deputised in midfield.
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