| Oct 3 2010 1:00PM |
| Denver Broncos | +6½ -110 | +230 | |
| Tennessee Titans | -6½ -110 | -270 |
| Oct 3 2010 1:00PM |
| Baltimore Ravens | +1½ -110 | | |
| Pittsburgh Steelers | -1½ -110 | |
| Oct 3 2010 1:00PM |
| Cincinnati Bengals | -3 -110 | -165 | |
| Cleveland Browns | +3 -110 | +145 |
| Oct 3 2010 1:00PM |
| Detroit Lions | +14½ -110 | +650 | |
| Green Bay Packers | -14½ -110 | -900 |
| Oct 3 2010 1:00PM |
| Carolina Panthers | +13½ -110 | +600 | |
| New Orleans Saints | -13½ -110 | -800 |
| Oct 3 2010 1:00PM |
| San Francisco 49ers | +6½ -110 | +240 | |
| Atlanta Falcons | -6½ -110 | -290 |
| Oct 3 2010 1:00PM |
| Seattle Seahawks | -1 -110 | | |
| St Louis Rams | +1 -110 | |
| Oct 3 2010 1:00PM |
| New York Jets | -5½ -110 | -250 | |
| Buffalo Bills | +5½ -110 | +210 |
| Oct 3 2010 4:05PM |
| Indianapolis Colts | -7 -110 | -370 | |
| Jacksonville Jaguars | +7 -110 | +300 |
| Oct 3 2010 4:05PM |
| Houston Texans | -3 -120 | -170 | |
| Oakland Raiders | +3 100 | +150 |
| Oct 3 2010 4:15PM |
| Arizona Cardinals | +8 -110 | +320 | |
| San Diego Chargers | -8 -110 | -400 |
| Oct 3 2010 4:15PM |
| Washington Redskins | +5½ -110 | +205 | |
| Philadelphia Eagles | -5½ -110 | -245 |
| Oct 3 2010 8:20PM |
| Chicago Bears | +3½ -110 | +170 | |
| New York Giants | -3½ -110 | -210 |
| Oct 4 2010 8:35PM |
| New England Patriots | -1 -110 | | |
| Miami Dolphins | +1 -110 | |